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Arrhythmogenic Cardiomyopathy Medical Slides

Arrhythmogenic cardiomyopathy is a heritable disorder caused most often by desmosomal gene mutations, leading to fibrofatty myocardial replacement and ventricular arrhythmias. It is a key teaching topic for inherited cardiomyopathy, sports cardiology, sudden cardiac death prevention, and cardiac MRI interpretation.

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Lecture outline6 slides
01

Genetics: desmosomal mutations, penetrance, and inheritance patterns

02

Pathology: progressive fibrofatty replacement of ventricular myocardium

03

2010 revised Task Force Criteria: major and minor diagnostic criteria

04

ECG findings: epsilon waves, T-wave inversions, and terminal activation delay

05

CMR findings: RV dilation, regional dyskinesia, and late gadolinium enhancement

06

Management: exercise restriction, ICD decisions, and antiarrhythmic therapy

Arrhythmogenic Cardiomyopathy lecture structure

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FAQ

How should the Task Force Criteria be taught?

Use a grid organized by structural dysfunction, tissue characterization, repolarization, depolarization, arrhythmias, and family history or genetics. Then show how major and minor criteria combine into definite, borderline, or possible diagnosis.

Why is exercise restriction important?

High-intensity exercise increases arrhythmic risk and accelerates disease progression in genotype-positive patients. A good teaching deck should connect mechanical stress at desmosomes to clinical exercise counseling.

How should left-dominant ACM be addressed?

Teach the shift from ARVC to ACM. Left-dominant disease can mimic myocarditis or dilated cardiomyopathy and often shows subepicardial or ring-like late gadolinium enhancement on cardiac MRI.

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