Peripheral Neuropathy Medical Slides
Generate publication-quality peripheral neuropathy lecture slides in 30 seconds. AI-powered content structured for clinical education.
Generate Peripheral Neuropathy DeckWhy teach Peripheral Neuropathy?
Peripheral neuropathy affects an estimated 2-3% of the general population, rising to 8% in adults over 55. Diabetic neuropathy is the most common cause in developed countries, while a systematic evaluation identifies treatable etiologies in up to 75% of cases. Teaching peripheral neuropathy requires a pattern-based diagnostic approach correlating clinical phenotype with electrodiagnostic findings to guide targeted investigation and treatment.
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Peripheral Neuropathy Presentation FAQ
How should the electrodiagnostic pattern approach be taught?
Present the key NCS patterns that narrow the differential: (1) uniform demyelination (slow velocities, prolonged distal latencies in all nerves) suggests hereditary neuropathy (CMT1A), (2) multifocal demyelination with conduction block suggests CIDP or MMN, (3) length-dependent axonal loss (reduced amplitudes, normal velocities) suggests metabolic/toxic causes, (4) asymmetric axonal loss suggests vasculitic neuropathy. This pattern recognition approach converts a broad differential into focused testing.
What workup algorithm should be presented for undifferentiated neuropathy?
Present a tiered approach: Tier 1 (all patients): glucose/HbA1c, B12 with methylmalonic acid, TSH, CBC, CMP, SPEP/UPEP with immunofixation. Tier 2 (if Tier 1 negative): ANA, ESR/CRP, hepatitis B/C, HIV, ACE level, antigliadin antibodies, heavy metals. Tier 3 (targeted): anti-MAG antibody, ganglioside antibodies (anti-GM1 for MMN), genetic testing for CMT, nerve biopsy for vasculitis. This systematic approach identifies a treatable cause in 50-75% of cases.
How should neuropathic pain pharmacotherapy be presented?
Present the evidence-based hierarchy per the 2017 NeuPSIG guidelines: first-line (TCAs — amitriptyline/nortriptyline, SNRIs — duloxetine/venlafaxine, gabapentinoids — gabapentin/pregabalin), second-line (tramadol, capsaicin 8% patch, lidocaine patch for focal pain), third-line (strong opioids as last resort). Emphasize NNT values: duloxetine NNT 6.4, pregabalin NNT 7.7, gabapentin NNT 6.3 — highlighting that most patients require combination therapy for adequate relief.
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